Synthesis of Optically Active .GAMMA.-Lactones with Lipase Catalyst
نویسندگان
چکیده
منابع مشابه
Facile synthesis of optically active gamma-lactones via lipase-catalyzed reaction of 4-substituted 4-hydroxybutyramides.
Lipase-catalyzed transesterification of racemic 4-substituted 4-hydroxybutyramides with succinic anhydride proceeded enantioselectively to afford (S)-succinic acid monoester and unreacted (R)-4-hydroxybutyramide derivative, which were separated easily by treatment with an alkaline solution. Both enantiomers were converted easily to optically active gamma-substituted gamma-butyrolactones.
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ژورنال
عنوان ژورنال: Journal of Oleo Science
سال: 2006
ISSN: 1345-8957,1347-3352
DOI: 10.5650/jos.55.629